Written in French. When the reign of Manuel I began in 1495, Lisbon, the capital of the kingdom of Portugal, was a multicultural city where wealth, new ideas and people from far away were flowing in. Within a refined court, artistic production echoed this opening to the world; the Lisbon workshops, supported by the royal commission, adopted a new way of painting, operating a very original synthesis between the pictorial inventions of the Flemish and Italian Renaissance and Portuguese culture. This book is a tribute to the talent of the Portuguese painters of the first half of the 16th